Analytical variation in factor VIII one-stage and chromogenic assays: Experiences from the ECAT external quality assessment programme.
Iris van MoortPiet MeijerDebby Priem-VisserAdriaan J van GammerenNathalie C V PéquériauxFrank W G LeebeekMarjon H CnossenMoniek P M de MaatPublished in: Haemophilia : the official journal of the World Federation of Hemophilia (2018)
In the lower range (<0.05 IU/mL), analytical variation of FVIII measurements is high in both OSA and CSA measurements. The variation in FVIII activity levels was partly explained by specific manufacturers. Further standardization of FVIII measurements and understanding of analytical variation is required.