Osteoarthritis in the Elderly Population: Preclinical Evidence of Nutrigenomic Activities of Flavonoids.
Flores NaselliDaniele BellaviaViviana CostaAngela De LucaLavinia RaimondiGianluca GiavaresiFabio CaradonnaPublished in: Nutrients (2023)
Osteoarthritis (OA) is a degenerative joint disease that is age-related and progressive. It causes the destruction of articular cartilage and underlying bone, often aggravated by inflammatory processes and oxidative stresses. This pathology impairs the quality of life of the elderly, causing pain, reduced mobility, and functional disabilities, especially in obese patients. Phytochemicals with anti-inflammatory and antioxidant activities may be used for long-term treatment of OA, either in combination with current anti-inflammatories and painkillers, or as an alternative to other products such as glucosamine and chondroitin, which improve cartilage structure and elasticity. The current systematic review provides a comprehensive understanding of the use of flavonoids. It highlights chondrocyte, cartilage, and subchondral bone activities, with a particular focus on their nutrigenomic effects. The molecular mechanisms of these molecules demonstrate how they can be used for the prevention and treatment of OA in the elderly population. However, clinical trials are still needed for effective use in clinical practice.
Keyphrases
- systematic review
- knee osteoarthritis
- obese patients
- anti inflammatory
- clinical trial
- middle aged
- clinical practice
- bariatric surgery
- rheumatoid arthritis
- community dwelling
- bone mineral density
- multiple sclerosis
- stem cells
- roux en y gastric bypass
- meta analyses
- randomized controlled trial
- spinal cord injury
- soft tissue
- spinal cord
- postmenopausal women
- neuropathic pain
- hyaluronic acid
- double blind
- placebo controlled