The Impact of Cytokines in Coronary Atherosclerotic Plaque: Current Therapeutic Approaches.
Panagiotis TsioufisPanagiotis TheofilisKonstantinos TsioufisDimitris TousoulisPublished in: International journal of molecular sciences (2022)
Coronary atherosclerosis is a chronic pathological process that involves inflammation together with endothelial dysfunction and lipoprotein dysregulation. Experimental studies during the past decades have established the role of inflammatory cytokines in coronary artery disease, namely interleukins (ILs), tumor necrosis factor (TNF)-α, interferon-γ, and chemokines. Moreover, their value as biomarkers in disease development and progression further enhance the validity of this interaction. Recently, cytokine-targeted treatment approaches have emerged as potential tools in the management of atherosclerotic disease. IL-1β, based on the results of the CANTOS trial, remains the most validated option in reducing the residual cardiovascular risk. Along the same line, colchicine was also proven efficacious in preventing major adverse cardiovascular events in large clinical trials of patients with acute and chronic coronary syndrome. Other commercially available agents targeting IL-6 (tocilizumab), TNF-α (etanercept, adalimumab, infliximab), or IL-1 receptor antagonist (anakinra) have mostly been assessed in the setting of other inflammatory diseases and further testing in atherosclerosis is required. In the future, potential targeting of the NLRP3 inflammasome, anti-inflammatory IL-10, or atherogenic chemokines could represent appealing options, provided that patient safety is proven to be of no concern.
Keyphrases
- coronary artery disease
- cardiovascular events
- rheumatoid arthritis
- patient safety
- clinical trial
- nlrp inflammasome
- percutaneous coronary intervention
- coronary artery bypass grafting
- cardiovascular disease
- coronary artery
- cancer therapy
- juvenile idiopathic arthritis
- oxidative stress
- disease activity
- randomized controlled trial
- aortic stenosis
- type diabetes
- study protocol
- emergency department
- heart failure
- climate change
- dendritic cells
- phase iii
- atrial fibrillation
- drug induced
- combination therapy
- systemic lupus erythematosus
- current status
- aortic valve
- adverse drug