Reciprocal and Autonomous Glucocorticoid and Androgen Receptor Activation in Salivary Duct Carcinoma.
Yoshitsugu MitaniSue-Hwa LinKristen B PytyniaRenata FerrarottoAdel K El-NaggarPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Our study, for the first time, demonstrates differential GR and AR expressions, autonomous GR and AR activation, and ligand-independent AR expression and activation in SDC cells. The findings provide critical information on the roles of GR and AR steroid receptors in SDC tumorigenesis and development of biomarkers to guide targeted steroid receptor therapy trials in patients with these tumors.