MicroRNAs in breast cancer: Roles, functions, and mechanism of actions.
Maryam AbolghasemiSadra Samavarchi TehraniTooba YousefiAnsar KarimianAta MahmoodpoorAliakbar GhamariFarhad Jadidi-NiaraghMehdi YousefiHossein Samadi KafilMilad BastamiMahdi EdalatiShirin EyvaziMohsen NaghizadehNiloufar TarghazehBahman YousefiAmin SafaMaryam MajidiniaVahid RameshkniaPublished in: Journal of cellular physiology (2019)
Breast cancer is one of the most lethal malignancies in women in the world. Various factors are involved in the development and promotion of the malignancy; most of them involve changes in the expression of certain genes, such as microRNAs (miRNAs). MiRNAs can regulate signaling pathways negatively or positively, thereby affecting tumorigenesis and various aspects of cancer progression, particularly breast cancer. Besides, accumulating data demonstrated that miRNAs are a novel tool for prognosis and diagnosis of breast cancer patients. Herein, we will review the roles of these RNA molecules in several important signaling pathways, such as transforming growth factor, Wnt, Notch, nuclear factor-κ B, phosphoinositide-3-kinase/Akt, and extracellular-signal-regulated kinase/mitogen activated protein kinase signaling pathways in breast cancer.
Keyphrases
- signaling pathway
- transforming growth factor
- nuclear factor
- epithelial mesenchymal transition
- cell proliferation
- pi k akt
- toll like receptor
- protein kinase
- poor prognosis
- stem cells
- tyrosine kinase
- transcription factor
- induced apoptosis
- squamous cell carcinoma
- polycystic ovary syndrome
- genome wide
- skeletal muscle
- machine learning
- papillary thyroid
- insulin resistance
- endoplasmic reticulum stress
- data analysis