p50 suppresses cytotoxic T lymphocyte effector function to regulate tumor immune escape and response to immunotherapy.

Chunwan LuJohn D KlementAlyssa D SmithDafeng YangJennifer L WallerDarren D BrowningDavid H MunnZhuoqi Liu

Published in: Journal for immunotherapy of cancer (2021)

Inflammation activates p50 that binds to the Gzmb promoter to repress granzyme B expression in T cells, resulting in CTL dysfunction to confer tumor immune escape and decreased response to anti-PD-1 immunotherapy.

Keyphrases

oxidative stress
poor prognosis
dna methylation
signaling pathway
regulatory t cells
dendritic cells
peripheral blood
binding protein
immune response