Elevated levels of harmful ROS and reduced antioxidant defense mechanisms are indicative of increased oxidative stress (OS), which is associated with SCZ. Previous research has shown that individuals with SCZ, including non-medicated, medicated, first-episode, and chronic patients, exhibit decreased levels of total antioxidants and GSH. Additionally, they have reduced antioxidant enzyme levels such as catalase (CAT), glutathione (GPx), and, superoxide dismutase (SOD) and lower serum levels of brain-derived neurotrophic factor (BDNF) in their brain tissue. The mentioned natural antioxidants may assist in reducing oxidative damage in individuals with SCZ and increasing BDNF expression in the brain, potentially improving cognitive function and learning ability.
Keyphrases
- oxidative stress
- dna damage
- end stage renal disease
- cerebral ischemia
- chronic kidney disease
- white matter
- resting state
- ejection fraction
- induced apoptosis
- ischemia reperfusion injury
- poor prognosis
- newly diagnosed
- diabetic rats
- bipolar disorder
- anti inflammatory
- cell death
- peritoneal dialysis
- multiple sclerosis
- prognostic factors
- brain injury
- reactive oxygen species
- blood brain barrier
- amyotrophic lateral sclerosis
- nitric oxide
- subarachnoid hemorrhage
- long non coding rna
- innate immune