Short-Chain Fatty Acids Produced by Ruminococcaceae Mediate α-Linolenic Acid Promote Intestinal Stem Cells Proliferation.

Jing XieLing-Fei LiTian-Yi DaiXin QiYan WangTiao-Zhen ZhengXiao-Yu GaoYun-Juan ZhangYu AiLi MaSong-Lin ChangFeng-Xian LuoYang TianJun Sheng

Published in: Molecular nutrition & food research (2021)

These results indicate that SCFAs produced by Ruminococcaceae mediate ALA promote ISCs proliferation by activating the Wnt/β-catenin signaling pathway, and suggest the possibility of ALA as a prebiotic agent for the prevention and treatment of intestinal mucositis.

Keyphrases

stem cells
signaling pathway
fatty acid
cell proliferation
radiation induced
cell therapy
bone marrow
replacement therapy
smoking cessation