Inhibition of JNK signalling mediates PPARα-dependent protection against intrahepatic cholestasis by fenofibrate.

Manyun DaiJulin YangMinzhu XieJiao LinMin LuoHuiying HuaGangming XuHante LinDanjun SongYuqing ChengBin GuoJinshun ZhaoFrank J GonzalezAiming Liu

Published in: British journal of pharmacology (2017)

These data suggest that the protective effects of fenofibrate against cholestasis-induced hepatic injury are dependent on PPARα and fenofibrate dose, and are mediated through inhibition of JNK signalling. This mechanism of fenofibrate protection against intrahepatic cholestasis may offer additional therapeutic opportunities for cholestatic liver diseases.

Keyphrases

drug induced
liver injury
signaling pathway
cell death
insulin resistance
induced apoptosis
high glucose
electronic health record
diabetic rats
big data
fatty acid
adipose tissue
metabolic syndrome
machine learning
endothelial cells
artificial intelligence