Exploring the Comprehensive Neuroprotective and Anticancer Potential of Afzelin.
Mateusz KciukNitika GargSanchit DhankharMonika SainiSomdutt MujwarSushma DeviSamrat ChauhanThakur Gurjeet SinghRandhir SinghBeata MarciniakAdrianna GielecińskaRenata KontekPublished in: Pharmaceuticals (Basel, Switzerland) (2024)
Neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, Huntington's disease, and others) and cancer, seemingly disparate in their etiology and manifestation, exhibit intriguing associations in certain cellular and molecular processes. Both cancer and neurodegenerative diseases involve the deregulation of cellular processes such as apoptosis, proliferation, and DNA repair and pose a significant global health challenge. Afzelin (kaempferol 3-O-rhamnoside) is a flavonoid compound abundant in various plant sources. Afzelin exhibits a diverse range of biological activities, offering promising prospects for the treatment of diseases hallmarked by oxidative stress and deregulation of cell death pathways. Its protective potential against oxidative stress is also promising for alleviating the side effects of chemotherapy. This review explores the potential therapeutic implications of afzelin, including its capacity to mitigate oxidative stress, modulate inflammation, and promote cellular regeneration in neurodegenerative and cancer diseases.
Keyphrases
- oxidative stress
- papillary thyroid
- dna damage
- dna repair
- cell death
- squamous cell
- global health
- ischemia reperfusion injury
- stem cells
- induced apoptosis
- squamous cell carcinoma
- public health
- signaling pathway
- endoplasmic reticulum stress
- childhood cancer
- cell cycle arrest
- human health
- cognitive decline
- blood brain barrier
- dna damage response
- heat shock
- replacement therapy
- climate change
- cerebral ischemia
- risk assessment
- smoking cessation
- rectal cancer