Clinical and preclinical advances in PSMA-Directed Antibody-Drug conjugates (ADCs): Current status and hope for the future.
Yousef MirzaeiAli Hussein MerBahia Fattah MaranLeila OmidvarFatemeh MisamogooeZahra AmirkhaniNafiseh Javaheri HaghighiNader BagheriZahra KeshtkaranBehzad RezaeiFarshad BargrizanehSaeed JahandidehNesa BarpourHosein ShahsavaraniAhmadreza BazyariMeghdad Abdollahpour-AlitappehPublished in: Bioorganic chemistry (2024)
Prostate-specific membrane antigen (PSMA) is a type II membrane glycoprotein overexpressed in a variety of tumors, especially in nearly all prostate cancers, which makes it a potentially attractive antigen for targeted cancer therapies. More importantly, PSMA, due to no shedding into circulation and efficient internalization after antibody binding, becomes a potential target for antibody-drug conjugates (ADCs), a valid and emerging paradigm of cancer treatment. Four and eight PSMA-directed ADCs have been or are currently being investigated in clinical trials (three of which failed to confirm the promising results while one is currently being evaluated in an ongoing clinical study) and preclinical studies, respectively, for the treatment of PSMA-positive solid tumors, especially prostate cancer. The present study aims to completely review clinical- and preclinical-stage PSMA-directed ADCs.
Keyphrases
- pet ct
- prostate cancer
- pet imaging
- current status
- clinical trial
- radical prostatectomy
- positron emission tomography
- cancer therapy
- cell therapy
- randomized controlled trial
- risk assessment
- computed tomography
- benign prostatic hyperplasia
- high resolution
- mesenchymal stem cells
- papillary thyroid
- young adults
- dna binding
- atomic force microscopy
- replacement therapy
- single molecule
- bone marrow
- high speed
- open label
- case control
- smoking cessation