IGF2 and IGF1R mRNAs Are Detectable in Human Spermatozoa.

Rossella Cannarella Rosita Angela Condorelli Sandro La Vignera Catia Bellucci Giovanni Luca Riccardo Calafiore Aldo Eugenio Calogero

Published in: The world journal of men's health (2019)

IGF2 and IGF1R mRNAs were found to be present in human spermatozoa and their transcription levels were positively correlated with sperm concentration and total sperm count. Spermatozoa are the only source of IGF2 mRNA since IGF2 is a paternally-inherited gene. Further studies are needed to evaluate its role in human fertilization.

Keyphrases

endothelial cells
binding protein
pi k akt
growth hormone
induced pluripotent stem cells
pluripotent stem cells
signaling pathway
genome wide
dna methylation