Frequency Rhythmic Electrical Modulation System (FREMS) to alleviate painful diabetic peripheral neuropathy: A pilot, randomised controlled trial (The FREMSTOP study).

Winston CrastoQuratul-Ain AltafDhiraj Ravindran SelvarajBukola JackVinod PatelSarfaraz NawazNarasimha MurthyNithya SukumarPonnusamy SaravananAbd A Tahrani

Published in: Diabetic medicine : a journal of the British Diabetic Association (2021)

FREMS might be used to treat individuals with PDPN inadequately controlled on two classes of neuropathic pain medications and is associated with improvements in pain severity and perceived impact of treatment. A larger, appropriately designed trial assessing its impact in this population is needed.

Keyphrases

neuropathic pain
study protocol
spinal cord
spinal cord injury
randomized controlled trial
type diabetes
clinical trial
depressive symptoms
chronic pain
pain management
phase ii
open label
combination therapy