This study was conducted to determine the effects of self-acupressure on sleep quality and fatigue in nurses working in medical clinics. A total of 64 nurses (n = 32 acupressure, n = 32 sham acupressure) participated in this prospective, 2-arm (1:1) study with an experimental design. In the study, both groups used the pressure points they were taught while performing self-acupressure 3 times per week for 4 weeks. After the intervention, the total mean score average of the acupressure group on the Pittsburg Sleep Quality Index and Fatigue Severity Scale was significantly lower than that of the sham acupressure group (P < .05). Self-acupressure is a noninvasive, easy-to-use, safe, and efficient complementary and integrated technique that nurses can use to improve their sleep quality and manage fatigue.