Plasma S1P Orchestrates the Reverse Transendothelial Migration of Aortic Intimal Myeloid Cells in Mice.
Chanele K PolenzCorey A ScipioneSharon J HydukMarwan G AlthagafiHisham M IbrahimMyron I CybulskyPublished in: Arteriosclerosis, thrombosis, and vascular biology (2024)
Functional and expression studies support a novel role for S1P signaling in the regulation of lipopolysaccharide-induced RTM and the homeostatic maintenance of aortic intimal MCs. Our data provide insight into how circulating plasma mediators help orchestrate intimal MC dynamics.
Keyphrases
- lipopolysaccharide induced
- inflammatory response
- aortic valve
- induced apoptosis
- left ventricular
- pulmonary artery
- poor prognosis
- cell cycle arrest
- aortic dissection
- dendritic cells
- acute myeloid leukemia
- electronic health record
- bone marrow
- big data
- high fat diet induced
- heart failure
- endoplasmic reticulum stress
- coronary artery
- binding protein
- oxidative stress
- cell death
- immune response
- pulmonary hypertension
- cell proliferation
- long non coding rna
- data analysis
- deep learning