ATF4-dependent heme-oxygenase-1 attenuates diabetic nephropathy by inducing autophagy and inhibiting apoptosis in podocyte.

Shizhu YuanXudong LiangWenfang HeMingzhu LiangJuan JinQiang He

Published in: Renal failure (2021)

ATF4 induces autophagy by enhancing the expression of HO-1, and inhibits podocyte apoptosis in DN. Treatment with the HO-1 agonist reduced proteinuria, apoptosis, and enhanced autophagy response, and thus improved renal function in DN mice.

Keyphrases

endoplasmic reticulum stress
diabetic nephropathy
cell death
oxidative stress
cell cycle arrest
signaling pathway
pi k akt
poor prognosis
transcription factor
high glucose
type diabetes
cell proliferation
high fat diet induced
binding protein
endothelial cells
replacement therapy
smoking cessation