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Combining Mendelian Randomization Analysis and 3D-QSAR to Investigate the Effectiveness of a New Series of Hydroxyquinolines in Osteoarthritis.

Zheng LianKunpeng SuHui LuChangpeng QuXuexiao Ma
Published in: Current medicinal chemistry (2024)
The research unearthed a robust causal interrelation between ADAMTS-5 and osteoarthritis via Mendelian randomization. Furthermore, a credible drug model targeting ADAMTS-5 was constructed. Collectively, these findings illuminate a path forward in the pursuit of target-specific drugs for osteoarthritis management in subsequent investigations.
Keyphrases
  • rheumatoid arthritis
  • knee osteoarthritis
  • randomized controlled trial
  • systematic review
  • molecular docking
  • wastewater treatment
  • emergency department
  • drug induced
  • electronic health record