Comment on "The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport".
Andrey G BaranovskiyNigar D BabayevaYinbo ZhangLuis BlancoYouri I PavlovTahir H TahirovPublished in: Science (New York, N.Y.) (2017)
O'Brien et al (Research Article, 24 February 2017, eaag1789) proposed a novel mechanism of primase function based on redox activity of the iron-sulfur cluster buried inside the C-terminal domain of the large primase subunit (p58C). Serious problems in the experimental design and data interpretation raise concerns about the validity of the conclusions.