Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APP swe and PS1 dE9 mutations.
Guilherme JuvenalCarine MeinerzAna Carolina AyupeHenrique Correia CamposEduardo Moraes ReisBeatriz Monteiro LongoMicheli Mainardi PillatHenning UlrichPublished in: Cell & bioscience (2024)
BK is an important immunomodulatory agent and enhances the immunological changes identified in transgenic neurospheres carrying the genetic load of AD. Bradykinin treatments modulate the expression rates of genes related to microglia-mediated neuroinflammation. Inhibiting bradykinin activity in Alzheimer's disease may slow disease progression.
Keyphrases
- immune response
- genome wide
- poor prognosis
- inflammatory response
- traumatic brain injury
- signaling pathway
- cognitive decline
- lps induced
- copy number
- neuropathic pain
- toll like receptor
- gene expression
- long non coding rna
- bioinformatics analysis
- genome wide identification
- blood brain barrier
- subarachnoid hemorrhage
- brain injury