Serum Small Extracellular Vesicles Proteome of Tuberculosis Patients Demonstrated Deregulated Immune Response.

Rakesh AryaDeepti DabralHossain Md FaruqueeHimangshu MazumdarSaurav Jyoti PatgiriTrinayan DekaRumi BasumataryRukuwe-U KupaChayale SemyWetetsho KapfoKevideme LiegiseInderjeet KaurTenzin ChoedonPurnima KumarRajendra Kumar BeheraPranjal DeoriReema NathKerekha KhaloLahari SaikiaVinotsole KhamoRanjan Kumar Nanda

Published in: Proteomics. Clinical applications (2019)

These important proteins, involved in neutrophil degranulation, plasma heme scavenging, kynurenine, and lipid metabolism, show deregulation in ATB patients. Identification of such a protein panel in circulating small EVs besides providing novel insights into their role in tuberculosis may prove to be useful targets to develop host-directed therapeutic intervention.

Keyphrases

end stage renal disease
immune response
ejection fraction
newly diagnosed
chronic kidney disease
mycobacterium tuberculosis
randomized controlled trial
prognostic factors
emergency department
patient reported outcomes
dendritic cells
toll like receptor
binding protein
human immunodeficiency virus
adverse drug