Single-Cell Transcriptome Analysis of Peripheral Neutrophils From Patients With Idiopathic Pulmonary Arterial Hypertension.
Lan WangJi ZhangYun-Long ZhangSu-Gang GongQin-Hua ZhaoXiao-Juan WangJia-Yu ZhaoRong JiangHong-Ling QiuHui-Ting LiJing HeShao-Fei LiuWolfgang M KueblerLan WangPublished in: Hypertension (Dallas, Tex. : 1979) (2023)
Our study yields a comprehensive dataset of the landscape of neutrophils in patients with IPAH. The predictive values of a neutrophil cluster characterized by higher MMP9 expression indicate a functional role for neutrophil-specific matrix metalloproteinases in the pathogenesis of pulmonary arterial hypertension.