Characterization of dendritic cells in human and experimental myocarditis.

Rudin PistulliElise AndreasSebastian KönigStefanie DrobnikDaniel KretzschmarIlonka RohmMichael LichtenauerBettina HeideckerMarcus FranzGita MallAtilla YilmazP Christian Schulze

Published in: ESC heart failure (2020)

Circulating DCs are reduced in human myocarditis and accumulate in the inflamed myocardium. MCS-18 treatment reduces DCs in EAM, leading to amelioration of inflammation and left ventricular remodelling during the acute phase of myocarditis. Our data further elucidate the role of DCs and their specific subsets in acute inflammatory cardiomyopathies.

Keyphrases

endothelial cells
dendritic cells
left ventricular
oxidative stress
induced pluripotent stem cells
heart failure
pluripotent stem cells
liver failure
electronic health record
intensive care unit
respiratory failure
hypertrophic cardiomyopathy
smoking cessation
aortic valve
transcatheter aortic valve replacement