β-Cell glucokinase expression was increased in type 2 diabetes subjects with better glycemic control.

Jingwen LiuHui FuFuyun KangYanqiu WangQicheng NiWeiqing WangQidi Wang

Published in: Journal of diabetes (2023)

Our study demonstrates that inductions of GCK enhanced adaptive UPR and UCN3 in human β-cells, which might be an adaptive mechanism during T2D progression. This finding provides a rationale for exploring novel molecules that activate β-cell GCK and thereby improve pharmacological treatment of T2D.

Keyphrases

glycemic control
type diabetes
single cell
cell therapy
blood glucose
poor prognosis
weight loss
metabolic syndrome
adipose tissue
long non coding rna