Analysis of LAP + and GARP + Treg subsets in peripheral blood of patients with neuromyelitis optica spectrum disorders.

Haobing CaiYu LiuXiaohua DongFei JiangHongliang LiSong OuyangWeifan YinTing HeQiuming ZengHuan Yang

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2023)

The proportion of Treg cells expressing LAP and GARP is downregulated, implying that Treg cells with the best inhibitory function are insufficient to maintain autoimmune homeostasis in NMOSD patients. Upregulation of Treg cells expressing LAP and GARP in NMOSD patients may be one of the mechanisms of glucocorticoid treatment.

Keyphrases

induced apoptosis
end stage renal disease
peripheral blood
cell cycle arrest
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
multiple sclerosis
cell death
cell proliferation
poor prognosis
long non coding rna