Mesenchymal Stem Cells and Selenium Nanoparticles Synergize with Low Dose of Gamma Radiation to Suppress Mammary Gland Carcinogenesis via Regulation of Tumor Microenvironment.
Omayma A R Abo-ZaidLaila A RashedSawsan M El-SonbatyAmira I Abu-ElftouhEsraa S A AhmedPublished in: Biological trace element research (2022)
Breast cancer is one of the most prevalent and deadliest cancers among women in the world because of its aggressive behavior and inadequate response to conventional therapies. Mesenchymal stem cells (MSCs) combined with green nanomaterials could be an efficient tool in cell cancer therapy. This study examined the curative effects of bone marrow-derived mesenchymal stem cells (BM-MSCs) with selenium nanoparticles (SeNPs) coated with fermented soymilk and a low dose of gamma radiation (LDR) in DMBA-induced mammary gland carcinoma in female rats. DMBA-induced mammary gland carcinoma as marked by an elevation of mRNA level of cancer promoter genes (Serpin and MIF, LOX-1, and COL1A1) and serum level of VEGF, TNF-α, TGF-β, CA15-3, and caspase-3 with the reduction in mRNA level of suppressor gene (FST and ADRP). These deleterious effects were hampered after treatment with BM-MSCs (1 × 10 6 cells/rat) once and daily administration of SeNPs (20 mg/kg body weight) and exposure once to (0.25 Gy) LDR. Finally, MSCs, SeNPs, and LDR notably modulated the expression of multiple tumor promoters and suppressor genes playing a role in breast cancer induction and suppression.
Keyphrases
- mesenchymal stem cells
- umbilical cord
- low dose
- bone marrow
- body weight
- cell therapy
- genome wide
- cancer therapy
- induced apoptosis
- high glucose
- diabetic rats
- genome wide identification
- high dose
- poor prognosis
- cell death
- endothelial cells
- dna methylation
- rheumatoid arthritis
- oxidative stress
- gene expression
- transcription factor
- binding protein
- papillary thyroid
- physical activity
- cell cycle arrest
- drug induced
- type diabetes
- single cell
- bioinformatics analysis
- polycystic ovary syndrome
- vascular endothelial growth factor
- childhood cancer
- skeletal muscle
- metabolic syndrome
- long non coding rna
- radiation therapy
- copy number
- prognostic factors
- protein kinase