Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types.

Simone EckerLu ChenVera PancaldiFrederik O BaggerJosé María FernándezEnrique Carrillo de Santa PauDavid JuanAlice L MannStephen WattFrancesco Paolo CasaleNikos SidiropoulosNicolas RapinAngelika Merkelnull nullHendrik G StunnenbergOliver StegleMattia FrontiniKate DownesTomi PastinenTaco W KuijpersDaniel RicoAlfonso ValenciaStephan BeckNicole SoranzoDirk S Paul

Published in: Genome biology (2017)

Our data highlight the importance of transcriptional and epigenetic variability for the key role of neutrophils as the first responders to inflammatory stimuli. We provide a resource to enable further functional studies into the plasticity of immune cells, which can be accessed from: http://blueprint-dev.bioinfo.cnio.es/WP10/hypervariability .

Keyphrases

gene expression
genome wide analysis
dna methylation
endothelial cells
transcription factor
electronic health record
induced pluripotent stem cells
oxidative stress
pluripotent stem cells
heat shock
big data
case control
machine learning