Plasma Markers of Neurologic Injury and Inflammation in People With Self-Reported Neurologic Postacute Sequelae of SARS-CoV-2 Infection.

Michael J PelusoHannah M SansCarrie A FormanAlyssa N NylanderHsi-En HoScott LuSarah A GoldbergRebecca HohViva TaiSadie E MunterAhmed ChennaBrandon C YeeJohn W WinslowChristos J PetropoulosJeffrey N MartinJ D KellyMatthew S DurstenfeldPriscilla Y HsuePeter W HuntMeredith GreeneFelicia C ChowJoanna HellmuthTimothy J HenrichDavid V GliddenSteven G Deeks

Published in: Neurology(R) neuroimmunology & neuroinflammation (2022)

Self-reported neurologic symptoms present approximately 4 months after SARS-CoV-2 infection are associated with elevations in markers of neurologic injury and inflammation at earlier time points. Some inflammatory pathways seem to be involved months after acute infection. Additional work will be needed to better characterize these processes and to identify interventions to prevent or treat this condition.

Keyphrases

oxidative stress
respiratory syndrome coronavirus
physical activity
depressive symptoms
coronavirus disease