DPP-4 inhibition enhanced renal tubular and myocardial GLP-1 receptor expression decreased in CKD with myocardial infarction.
Seung Jung KimSoon Kil KwonHye-Young KimSun Moon KimJang-Whan BaeJoong-Kook ChoiPublished in: BMC nephrology (2019)
In CKD with MI/R, linagliptin attenuated renal injury and increased renal and myocardial GLP-1R expression. These data suggest that activation of renal and myocardial GLP-1R expression may provide both cardio- and renoprotective effects.