Quantitative MRI reveals heterogeneous impacts of treatment on diseased bone marrow in a mouse model of myelofibrosis.
Tanner H RobisonWinston LeeKathryn E LukerKristen PettitMoshe TalpazThomas L ChenevertBrian D RossGary D LukerPublished in: Magnetic resonance in medicine (2024)
Quantitative MRI revealed modest, heterogeneous improvements in bone marrow disease when treating mice with established myelofibrosis. These results emphasize the value of bone marrow MRI to assess treatment in preclinical models and the potential to advance clinical trials for patients.
Keyphrases
- bone marrow
- mesenchymal stem cells
- magnetic resonance imaging
- contrast enhanced
- clinical trial
- mouse model
- end stage renal disease
- diffusion weighted imaging
- chronic kidney disease
- high resolution
- newly diagnosed
- peritoneal dialysis
- computed tomography
- stem cells
- randomized controlled trial
- combination therapy
- single cell
- risk assessment
- climate change
- patient reported outcomes
- high fat diet induced
- patient reported
- study protocol