Impact of the Gut Microbiota on Atorvastatin Mediated Effects on Blood Lipids.
Friederike ZimmermannJohann RoesslerDavid SchmidtAndrzej JasinaPaul SchumannMartina GastWolfgang PollerDavid LeistnerHector GiralNicolle KränkelAdelheid KratzerSven SchuchardtMarkus M HeimesaatUlf LandmesserArash HaghikiaPublished in: Journal of clinical medicine (2020)
Our findings support a regulatory impact of atorvastatin on the gut microbial profile and, in turn, demonstrate a crucial role of the gut microbiome for atorvastatin-related effects on blood lipids. These results provide novel insights into potential microbiota-dependent mechanisms of lipid regulation by statins, which may account for variable response to statin treatment.