Biomimetic human bone marrow tissues: models to study hematopoiesis and platforms for drug testing.
Andrés García-GarcíaIvan MartinPublished in: Molecular & cellular oncology (2021)
We propose an in vitro 3D culture system combining perfusion bioreactors, scaffolds and human primary cells to engineer fully-humanized, biomimetic and customizable bone marrow tissues. This system could serve as a model to investigate human hematopoietic stem cell niches, but also as a drug testing platform for pharmaceutical research and patient-personalized medicine.
Keyphrases
- bone marrow
- endothelial cells
- hematopoietic stem cell
- induced pluripotent stem cells
- mesenchymal stem cells
- pluripotent stem cells
- gene expression
- induced apoptosis
- emergency department
- magnetic resonance imaging
- high throughput
- tissue engineering
- wastewater treatment
- cell proliferation
- case report
- oxidative stress
- signaling pathway
- cell cycle arrest
- electronic health record