Pilot Study of the Effects of Chronic Intracerebroventricular Infusion of Human Anti-IgLON5 Disease Antibodies in Mice.
Sara AlventeGabriele MatteoliLaura Molina-PorcelJon LandaMercedes AlbaStefano BastianiniChiara BerteottiFrancesc GrausViviana Lo MartireLidia SabaterGiovanna ZoccoliAlessandro SilvaniPublished in: Cells (2022)
The results of our pilot study suggest, but do not prove, that chronic ICV infusion of mice with Pt-IgG may elicit neuropathological, respiratory, and motor alterations. These results should be considered as preliminary until replicated in larger studies taking account of potential sex differences in mice.