Artesunate monotherapy versus artesunate plus quinine combination therapy for treatment of imported severe malaria: a TropNet retrospective cohort study.

Annarita BottaAgnese ComelliIacopo VellereFlavia ChechiLeila BianchiGardini GiuliaLina Rachele TomasoniMichele SpinicciLuisa GalliFrancesco CastelliAlessandro BartoloniLorenzo Zammarchi

Published in: Infection (2022)

IVA + IVQ treatment did not show better outcome with respect to IVA monotherapy. AEs were more frequent in the IVA + IVQ group compared to the monotherapy. Further studies are necessary to investigate whether IVA + IVQ could be an efficient strategy to treat severe malaria cases in areas at high risk of artemisinin resistance.

Keyphrases

combination therapy
plasmodium falciparum
open label
early onset
randomized controlled trial
clinical trial