Intermittent Hypobaric Hypoxic Preconditioning Provides Neuroprotection by Increasing Antioxidant Activity, Erythropoietin Expression and Preventing Apoptosis and Astrogliosis in the Brain of Adult Rats Exposed to Acute Severe Hypoxia.
Débora Coimbra-CostaFernando GarzónNorma AlvaTiago C C PintoFernando AguadoJoan Ramon TorrellaTeresa CarbonellRamón RamaPublished in: International journal of molecular sciences (2021)
IHH exerted neuroprotection against ASH-induced oxidative injury by preventing oxidative stress and inhibiting the apoptotic cascade, which was associated with NF-κB downregulation and EPO upregulation.
Keyphrases
- oxidative stress
- cerebral ischemia
- signaling pathway
- diabetic rats
- poor prognosis
- drug induced
- subarachnoid hemorrhage
- ischemia reperfusion injury
- cell death
- brain injury
- induced apoptosis
- pi k akt
- blood brain barrier
- liver failure
- cell proliferation
- cell cycle arrest
- high glucose
- dna damage
- endothelial cells
- long non coding rna
- respiratory failure
- high intensity
- early onset
- endoplasmic reticulum stress
- white matter
- aortic dissection
- resting state
- binding protein
- municipal solid waste
- lps induced
- sewage sludge
- nuclear factor
- multiple sclerosis
- inflammatory response
- anti inflammatory
- childhood cancer
- functional connectivity