Quercetin 7-rhamnoside from Sorbaria sorbifolia exerts anti-hepatocellular carcinoma effect via DHRS13/apoptotic pathway.

Zhaohua XuYing DangXu Chennull HaiWenzhi YaoWenchao KouJiamei ZhangJianping ShiYu DongJing Li

Published in: Phytomedicine : international journal of phytotherapy and phytopharmacology (2024)

Elevated DHRS13 expression contributes to HCC progression. Q7R effectively downregulates DHRS13, encouraging apoptosis and impeding HCC growth. As a result, Q7R shows potential as a therapeutic agent for HCC treatment, targeting the apoptotic pathway through DHRS13 regulation.

Keyphrases

cell death
cell cycle arrest
poor prognosis
oxidative stress
endoplasmic reticulum stress
cancer therapy
binding protein
signaling pathway
combination therapy
long non coding rna
replacement therapy
climate change
smoking cessation