A prospective, randomized, double-blind trial of intravenous chlorpromazine versus intravenous prochlorperazine for the treatment of acute migraine in adults presenting to the emergency department.
Sarah Ellen HodgsonAndrew M HardingElyssia M BourkeDavid McDonald TaylorShaun Lawrence GreenePublished in: Headache (2021)
Both chlorpromazine and prochlorperazine are efficacious treatments for acute migraine in adult patients presenting to the ED. This trial found no evidence of superiority of either agent over the other. Caution should be used when prescribing these medicines in the borderline hypotensive patient; in that circumstance, prochlorperazine should be preferentially used.
Keyphrases
- emergency department
- phase iii
- liver failure
- case report
- study protocol
- clinical trial
- phase ii
- respiratory failure
- double blind
- high dose
- drug induced
- aortic dissection
- placebo controlled
- primary care
- open label
- randomized controlled trial
- adverse drug
- intensive care unit
- combination therapy
- acute respiratory distress syndrome
- mechanical ventilation