GAB1 overexpression identifies hedgehog-activated anterior skull base meningiomas.

Julien BoettoJulie LerondMatthieu PeyreSuzanne TranPauline MarijonMichel KalamaridesFranck Bielle

Published in: Neuropathology and applied neurobiology (2021)

The assessment of GAB1 expression by an immunohistochemical score is a fast and cost-efficient tool to screen anterior skull base meningiomas for activation of the Hh pathway. It could facilitate the identification of selected cases amenable to sequencing for Hh pathway genes as predictive markers for targeted therapy.

Keyphrases

genome wide
bioinformatics analysis
poor prognosis
cell proliferation
high throughput
transcription factor
gene expression
long non coding rna
genome wide analysis