Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis.
Joseph N JarvisDavid S LawrenceDavid B MeyaEnock KagimuJohn KasibanteEdward MpozaMorris K RutakingirwaKenneth SsebambuliddeLillian TugumeJoshua RheinDavid R BoulwareHenry C MwandumbaMelanie MoyoHenry MzinganjiraCecilia KanyamaMina C HosseinipourChimwemwe ChawingaGraeme MeintjesCharlotte SchutzKyla CominsAchita SinghConrad MuzooraSamuel JjunjuEdwin NuwagiraMosepele MosepeleTshepo LeemeKeatlaretse SiamisangChiratidzo E NdhlovuAdmire HlupeniConstantine MutataErik van WidenfeltTao ChenDuolao WangWilliam HopeTimothée Boyer-ChammardAngela LoyseSíle F MolloyNabila YoussoufOlivier LortholaryDavid G LallooShabbar JaffarThomas S Harrisonnull nullPublished in: The New England journal of medicine (2022)
Single-dose liposomal amphotericin B combined with flucytosine and fluconazole was noninferior to the WHO-recommended treatment for HIV-associated cryptococcal meningitis and was associated with fewer adverse events. (Funded by the European and Developing Countries Clinical Trials Partnership and others; Ambition ISRCTN number, ISRCTN72509687.).