Profiling of immune-related gene expression in children with familial hypercholesterolaemia.

I Narverud Jacob J ChristensenS S BakkeS M UlvenA RundbladP AukrustT EspevikM P BogsrudKjetil RetterstølT UelandB HalvorsenK B Holven

Published in: Journal of internal medicine (2019)

FH children display higher PBMC expression of immune-related genes mapped to several pathways, including T and B cells, and TNFSF than healthy children. Our results suggest that LDL-C plays an important role in modulating expression of different immune-related genes, and novel data on the involvement of these pathways in the early atherosclerosis may represent future therapeutic targets for prevention of atherosclerotic progression.

Keyphrases

gene expression
young adults
poor prognosis
cardiovascular disease
dna methylation
signaling pathway
type diabetes
binding protein
single cell
electronic health record
machine learning
early onset
long non coding rna
data analysis