A Multicenter Randomized Trial of Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis.
Joel M DulhuntyJason Alexander RobertsJoshua S DavisSteven A R WebbRinaldo BellomoCharles GomersallCharudatt ShirwadkarGlenn M EastwoodJohn MyburghDavid L PatersonTherese StarrSanjoy K PaulJeffrey Lipmannull nullPublished in: American journal of respiratory and critical care medicine (2016)
In critically ill patients with severe sepsis, there was no difference in outcomes between β-lactam antibiotic administration by continuous and intermittent infusion. Australian New Zealand Clinical Trials Registry number (ACT RN12612000138886).