Transcriptomic and epigenetic landscape of nimorazole-enhanced radiochemotherapy in head and neck cancer.

María José BessoVerena BittoLydia KoiWahyu Wijaya HadiwikartaCristina Conde-LopezRosemarie Euler-LangeMahnaz BonrouhiKarolin SchneiderAnnett LingeMechthild KrauseMichael BaumannIna Kurth

Published in: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (2024)

In the present study, we found that nimorazole non-responder models were characterized by upregulation of genes involved in Retinol metabolism and xenobiotic metabolic process pathways, which might contribute to identify mechanisms of resistance to nitroimidazole compounds and potentially expand the repertoire of therapeutic options to treat HNSCC.

Keyphrases

single cell
dna methylation
gene expression
poor prognosis
cell proliferation
locally advanced
rna seq