Implant-associated gene expression in the jaw bone of smokers and nonsmokers: A human study using quantitative qPCR.
Shariel SayardoustOmar OmarOla NorderydPeter ThomsenPublished in: Clinical oral implants research (2018)
The implant-adherent cells are more sensitive to surface properties and smoking conditions than the cells in the peri-implant bone. Smoking imposes inhibitory effects on the initial molecular events of osseointegration in the human bone-implant interface. The surface properties of oxidized implants appear to have a beneficial effect on osseointegration by mitigating the smoking-induced negative effects.
Keyphrases
- soft tissue
- smoking cessation
- induced apoptosis
- gene expression
- endothelial cells
- bone mineral density
- cell cycle arrest
- high glucose
- dna methylation
- pluripotent stem cells
- bone loss
- bone regeneration
- high resolution
- endoplasmic reticulum stress
- oxidative stress
- mass spectrometry
- body composition
- postmenopausal women
- drug induced
- single molecule