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Pleiotropic Effects of a KCNQ1 Variant on Lipid Profiles and Type 2 Diabetes: A Family-Based Study in China.

Xiaowen WangJunhui WuYao WuMengying WangZijing WangTao WuDafang ChenXun TangXueying QinYi-Qun WuYong-Hua Hu
Published in: Journal of diabetes research (2020)
KCNQ1 had pleiotropic effects on lipids and T2DM, and the unexpected genetic effect on association of HDL-C with T2DM was observed, indicating the different pathways to lipids and T2DM. Further research studies are needed to verify potential biological mechanisms.
Keyphrases
  • glycemic control
  • type diabetes
  • fatty acid
  • cardiovascular disease
  • copy number
  • gene expression
  • human health