Pleiotropic Effects of a KCNQ1 Variant on Lipid Profiles and Type 2 Diabetes: A Family-Based Study in China.

Xiaowen WangJunhui WuYao WuMengying WangZijing WangTao WuDafang ChenXun TangXueying Qin Yi-Qun Wu Yong-Hua Hu

Published in: Journal of diabetes research (2020)

KCNQ1 had pleiotropic effects on lipids and T2DM, and the unexpected genetic effect on association of HDL-C with T2DM was observed, indicating the different pathways to lipids and T2DM. Further research studies are needed to verify potential biological mechanisms.

Keyphrases

glycemic control
type diabetes
fatty acid
cardiovascular disease
copy number
gene expression
human health