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The Safety and Efficacy of Lansoprazole plus Metoclopramide among Neonates with Gastroesophageal Reflux Disease Resistant to Conservative Therapy and Monotherapy: A Clinical Trial.

Peymaneh Alizadeh TaheriElahe ValidadKambiz Eftekhari
Published in: International journal of pediatrics (2021)
The response rate was significant in each group after one week and one month of treatment, but it was significantly higher in the "lansoprazole plus metoclopramide" group compared with the "ranitidine plus metoclopramide" group. The combination of each acid suppressant with metoclopramide led to a higher response rate in comparison with monotherapy used before intervention. This study has been registered at the Iranian Registry of Clinical Trails (RCT20160827029535N3).
Keyphrases
  • clinical trial
  • combination therapy
  • open label
  • gastroesophageal reflux disease
  • randomized controlled trial
  • study protocol
  • stem cells
  • double blind