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Time-related biases in pharmacoepidemiology.

Samy SuissaSophie Dell'Aniello
Published in: Pharmacoepidemiology and drug safety (2020)
Many observational studies of new indications for older drugs reporting unrealistic effectiveness were affected by avoidable time-related biases. The apparent effectiveness often disappears with proper design and analysis. Future studies should consider these time-related issues to avoid severely biased results.
Keyphrases
  • randomized controlled trial
  • systematic review
  • magnetic resonance imaging
  • physical activity
  • drug induced
  • middle aged
  • diffusion weighted imaging