Time-related biases in pharmacoepidemiology.
Samy SuissaSophie Dell'AnielloPublished in: Pharmacoepidemiology and drug safety (2020)
Many observational studies of new indications for older drugs reporting unrealistic effectiveness were affected by avoidable time-related biases. The apparent effectiveness often disappears with proper design and analysis. Future studies should consider these time-related issues to avoid severely biased results.