Norisoboldine, a Natural Alkaloid from Lindera aggregata (Sims) Kosterm, Promotes Osteogenic Differentiation via S6K1 Signaling Pathway and Prevents Bone Loss in OVX Mice.

Shiming LiWenliang YanKainong SunJingyuan MiaoZichao LiuJiayang XuXiaoyu Wang Bo LiQian Zhang

Published in: Molecular nutrition & food research (2024)

NOR effects in enhancing osteoblast-induced bone formation via S6K1 pathway, suggesting the potential of NOR in osteoporosis treatment by increasing bone formation.

Keyphrases

bone loss
signaling pathway
mesenchymal stem cells
bone marrow
high glucose
postmenopausal women
diabetic rats
pi k akt
epithelial mesenchymal transition
mouse model
oxidative stress
adipose tissue
human health
replacement therapy