Phase II Investigation of TVB-2640 (denifanstat) with Bevacizumab in Patients with First Relapse High-Grade Astrocytoma.

William James Kelly Adolfo Enrique Diaz Duque Joel E Michalek Brandon Konkel Laura Caflisch Yidong Chen Sarath Chand Pathuri Vinu Madhusudanannair Kunnuparampil John Floyd Andrew J Brenner

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

In this phase II study of relapsed high-grade astrocytoma, TVB-2640 was found to be a well-tolerated oral drug that could be safely combined with bevacizumab. The favorable safety profile and response signals support the initiation of a larger multicenter trial of TVB-2640 plus bevacizumab in astrocytoma.

Keyphrases

high grade
phase ii
open label
phase ii study
clinical trial
metastatic colorectal cancer
low grade
phase iii
placebo controlled
double blind
study protocol
acute myeloid leukemia
acute lymphoblastic leukemia
randomized controlled trial
multiple myeloma
diffuse large b cell lymphoma
hodgkin lymphoma
adverse drug