Protective effect of apelin preconditioning in a rat model of hepatic ischemia reperfusion injury; possible interaction between the apelin/APJ system, Ang II/AT1R system and eNOS.
Maha M SabryNagwa Mahmoud RamadanBasant A Al DrenyLaila A RashedAyman Abo El EneinPublished in: United European gastroenterology journal (2019)
Apelin-13 reduced hepatic ischemic reperfusion injury. This protection could be related to the suppression of hepatic angiotensin type 1 receptor expression and elevation of hepatic apelin level and endothelial nitric oxide synthase expression, which counteracts the pathologic effects of Ang II/angiotensin type 1 receptor. An interaction exists between apelinergic, renin-angiotensin systems and endothelial nitric oxide synthase in hepatic ischemic reperfusion pathophysiology.
Keyphrases
- nitric oxide synthase
- ischemia reperfusion injury
- nitric oxide
- angiotensin ii
- cerebral ischemia
- angiotensin converting enzyme
- endothelial cells
- acute myocardial infarction
- oxidative stress
- poor prognosis
- brain injury
- subarachnoid hemorrhage
- neoadjuvant chemotherapy
- coronary artery disease
- atrial fibrillation
- lymph node