Age-related differences of γ-aminobutyric acid (GABA)ergic transmission in human colonic smooth muscle.
Maria Grazia ZizzoAdele CicioStefania RaimondoRiccardo AlessandroRosa SerioPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2021)
Our results reveal age-related differences in GABAergic transmission in human colon. At all the age tested GABA regulates muscular contractility modulating the activity of the intrinsic neurons. Activation of GABAA receptor, through acetylcholine release, induces contraction, which increases in amplitude with age. GABAB receptor activation leads to neural release of NO and purines, being a loss of purinergic-component in aged group.