Influence of genetic variants in FADS2 and ELOVL2 genes on BMI and PUFAs homeostasis in children and adolescents with obesity.
Alice MaguoloChiara ZusiAlice GiontellaEmanuele Miraglia Del GiudiceAngela TagettiCristiano FavaAnita MorandiClaudio MaffeisPublished in: International journal of obesity (2005) (2020)
Common variants in the FADS2 and ELOVL2 genes were associated with BMI in a large population of obese Italian children. These SNPs were associated with alterations in LC-PUFAs homeostasis, not accompanied by modifications of plasma lipids or HOMA-IR. These findings provide additional support to the genetics accounting for BMI interindividual variability and the molecular basis of obesity.
Keyphrases
- weight gain
- weight loss
- body mass index
- genome wide
- metabolic syndrome
- insulin resistance
- fatty acid
- type diabetes
- high fat diet induced
- adipose tissue
- bariatric surgery
- copy number
- bioinformatics analysis
- genome wide identification
- young adults
- dna methylation
- genome wide analysis
- physical activity
- skeletal muscle
- liquid chromatography
- transcription factor